How your Genetics can Impact your Weight Loss
If you feel like you can’t lose weight no matter what you try, genetics may be playing a role, albeit small. The exciting news is that through gene/environment interactions, genes are being switched on and off based on lifestyle cues. You have more control over the way that your genes are expressed than we ever thought possible. Furthermore, the science of genetics has shown that great genes come from turning genes on and off to your advantage. If you’re struggling with weight gain/weight loss resistance, you want to know about the genes that may be driving you to be more hungry or addicted to carbs, so that you can do something about how those genes are being expressed.
Below are three of the most common genes impacting your metabolism and weight loss or gain:
FTO Gene: Impacts Food Intake
One of the most studied obesity genes is FRO which stands for Fat Mass and Obesity Associated. FTO seems to act as a nutrient sensor, affecting the amount of food a person wants to eat, and their hunger. Variations in the gene that encodes for FTO could affect the ability of FTO to regulate food intake and lower satiety. Scientists have found that people with certain variations in this gene have a higher BMI. What can turn off this gene naturally? Regular physical activity is the answer for those who have the gene and would like to keep it “dormant”.
PPARG Gene: Impacts Fat Metabolism
Another gene affecting weight gain is the one that encodes for PPARG, a protein involved in fat metabolism. When activated, PPARG creates fat cells and helps with the uptake of dietary fats from your blood. Too much activation of PPARG can cause weight gain and increase the risk for heart disease, diabetes, and stroke. Obese individuals have much higher amounts of this protein in their fat tissue. In addition, studies have shown that postmenopausal women who have variations PPARG gain more weight than those who don’t.
ADRB2 Gene: Impacts Fat Breakdown
The adrenergic beta-2 surface receptor gene (ADRB2) codes for a protein that plays an important role in the breakdown of fat. (When the hormone epinephrine is released, it can bind to ADRB2, which increases energy by breaking down fat molecules.) Certain variations are associated with an increased risk of metabolic syndrome in women, result in risk factors that display an increase risk of diabetes mellitus and cardiovascular disease. Prevalence of metabolic syndrome is higher in middle-aged women than middle-aged men, as is greater cardiovascular risk.